To do something that is opposite to what is usually done or accepted.

मुख्य धारा के विरुद्ध होना, सामान्य व्यवहार के विपरीत जाना

English Usage: His decision to leave a high-paying job and travel the world went against the grain of what most people would do.

Hindi Usage: उसका एक ऊँची सैलरी वाली नौकरी छोड़कर दुनिया घूमने का निर्णय रिवाज के खिलाफ था।